Microtubules: Structure and Functions

The cytoplasm of the eukaryotic cell contains numerous hollow ultrafine non-membranous tubules made up of tubulin protein and involved in the movement, and determination of cell shape is known as microtubules. Besides tubulin, microtubules also contain many other proteins, such as kinesin and dynein. The combination of microtubules and microfilaments forms the cytoskeleton of the cell. Microtubules are responsible for the movement of the cell membrane, organelles, and cytoplasm.

image of Microtubule

The electron microscope has revealed that the cytoplasmic matrix of most eukaryotic cells contains microtubule and micro-filaments. In addition to this, the microtubules also occur in cilia, flagella, centrioles, and basal bodies, etc. and microfilaments are found in the axons of the neurons.

Microtubules are polymers of tubulin that have fine hollow cylinders of variable length. Generally, the microtubule consists of 13 protofilaments in the tubular arrangement. In some bacterial, microtubule consists of a ring of five protofilaments.

A microtubule can grow up to 50 µm in length and is highly dynamic. Tubules are very stiff in nature, and the outer diameter of a microtubule ranges from 23- 27 nm while the inner diameter from11-15 nm. The wall of the microtubule is about 60 Å in thickness and made up of alternating helix of α-tubulin and β-tubulin. Tubulin is a globular protein in nature. The α- and β-tubulins combine and form one dimer. Electron microscopic structure of cells has revealed that spindle fibers are created by the aggregation of much smaller fibers called microtubules.

Functions of Microtubules

  • They form a supporting framework or cytoskeleton and give shape to the cell.
  • They form the mitotic apparatus (spindles) consisting of bundles of microtubules.
  • They help to make up the internal structure of flagella and cilia.
  • They are related to the movement, such as the undulation of cilia and flagella.
  • Microtubules are involved in the transport of macromolecules within the cells.
  • During cell differentiation, cells change their shapes with the help of microtubules.
  • They also take part in cell division. In this case, they make up the mitotic spindles as the major constituents.
  • They are involved in various cellular processes, such as the movement of the secretory vesicles and organelles.
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