Taenia solium: Morphology, Life Cycle and Pathogenesis

Taenia solium is a parasitic organism which belongs to the family Taeniidae under order Cyclophyllidea of class Cestoda. It is also known as the pork tapeworm. It is occurred amongst the pork eaters all over the world. It is the armed tapeworm of human. Adult worm lives in the small intestine (upper jejunum) of human.

Systematic Position

Phylum: Platyhelminthes
Class: Cestoda
Order: Cyclophyllidea
Family: Taeniidae
Genus: Taenia
Species: Taenia solium

Definitive Host: Human. Adult and larval forms are found.
Intermediate Host: Pig and human.

Morphology of Taenia solium

Taenia solium has flat, ribbon-like body with white in color. It is triploblastic acoelomate and can grow up to 2 to 3 meters or more in length.

Taenia solium: Image credit-wikimedia commons

The scolex (head) is 1 mm, globular in shape that bears four citcular suckers and a rostellum with a double row of about 30 alternating large and small hooklets.

Scolex of T. solium: Image credit-Wikimedia Commons

Neck is short and after it, the elongated body, known as strobila is present. The entire body is covered by tegument. The strobila is divided into proglottides or segments. These may be 800 to 900 in number (less than 1000). A gravid segment is about 12X6 mm, i.e. longer than broader.

The gravid proglottides contains lots of fertilized eggs which are spherical in shape with 35 to 42 µm in diameter.

Gravid Proglottid of T. solium: Image credit: wikimedia commons

The genital pores are situated marginally and alternate irregularly between right and left margins. The gravid uterus consists of a central main stem with 5 to 10 compound lateral branches on each side. The worm has a life span of about 25 years.

Life Cycle of Taenia solium

Human is the only definitive host. The adult worm is found only in man following eating of undercooked pork containing cysticercus cellulosae larvae.

The adult worms live in the intestine (upper part of jejunum) of man. The gravid proglottid liberates 30,000 to 50,000 eggs before or after leaving the host. Eggs and segments are passed in the stools and contaminate vegetations and water. The eggs are swallowed by pig or human.

Life cycle of T. Solium: Image credit-wikimedia commons

The larvae liberate from the eggs in stomach, penetrate the intestinal mucosa and settle in different parts particularly muscles of pig or human. Here they develop into larva from cysticercus cellulosae. This may also occur due to autoinfection in individuals infected with adult worm.

The egg regurgitates from the intestine into the stomach where it hatches and the larva enters the blood circulation. The adult worm is formed in intestine of human from living larvae ingested with undercooked pork meat.

Pathogenesis and Clinical Features

Adult Worms

Adult worm infection is usually asymptomatic. The diseases are caused by the adult worm, known as taeniasis. If you untreated, the infections with Taenia solium last for about 2–3 years. In many cases, infected people do not show any symptoms up to one year.

The most common intestinal symptoms of taeniasis include:

Abdominal pain;
Nausea;
Vomiting;
Constipation;
Diarrhea, etc.

Cysticercosis

Cysticercus cellulosae larvae are usually found in skeletal muscle and subcutaneous tissues. There may be serious effects due to presence of the larvae in vital organs like brain, eye, etc. The cysticercus may be calcified. Nodules found in subcutaneous tissue. In symptomatic cases, the following symptoms can be expressed:

Headaches;
Dizziness, and
Seizures, etc.

If the brain is infected by the cysticercus larvae then it is known as neurocysticercosis. It is the leading cause of seizures worldwide. In heavy brain infection especially in children, the following symptoms are expressed:

Encephalitis;
Epilepsy;
Personally change;
Staggering gait;
Signs of internal hydrocephalous;
Eye blindness;
Blood may show eosinophilia (20 t0 60% eosinophils).

Diagnosis

Stool should be examined under microscope to detect eggs and proglottides.
To detect cysticercus cellulosae, biopsy examination of a subcutaneous nodule should be done.
X-ray examination may be helpful if the larva is calcified.
Blood examination may show eosinophilia (20 to 60% eosinophils).
Antibody detection should be done through fluorescent antibody test.

Prevention

Under cooked pork should be avoided;
Vegetables contaminated with feces should be avoided;
Disposal of human feces should be done properly;
High level of sanitation should be maintained;
Fecal contaminated free pig feed should be insured to the pig;
Pork should be cooked properly;
Freezing the meat should be done at −10 °C for 5 days;

Treatment

Praziquantel is used to treat for intestinal infection. In this case, 5 to 10 mg/kg praziquantel is used as single dose orally to eradicate adult worms.
You can also use niclosamide as a single dose for adult. In this case, 4 tablets (500 mg each) are chewed or swallowed at a time. For children, the dose should be 5o mg/kg as a single dose.
Corticosteroids, antiseizure drugs, and sometimes praziquantel or albendazole are effective for neurocysticercosis.
In many cases, surgery may be needed to remove obstructive hydrocephalus or spinal or ocular cysticercosis.

Difference between Taenia solium and Taenia saginata

Characteristic Features	Taenia saginata	Taenia solium
Occurrence	Not rare	Rare
Definitive host	Man	Man
Intermediate host	Cattle	Man and pig
Body length	5-10 meters	2-3 meters
Scolex	Large, quadrate. No rostellum or hooks	Small, globular with rostellum and hooks
Neck	Long	Short
Proglottides	1000-2000	Less than 1000
Uterus	Lateral branches, 15 to 30 on each side	Lateral branches, 5 to 10 on each side
Vagina	Sphincter present	Sphincter absent
Ovaries	Two, no accessory lobe	Two with an accessory lobe
Testes	300 to 400 follicles	150 to 200 follicles
Genital pore	Alternate and irregular	Alternate and irregular
Expulsion of segments	Expelled singly	Expelled in chains of 5 or 6
Egg	Spherical in shape	Spherical in shape

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